E-75, while not as impressive looking as E-100 is quite a beast itself and a rightful successor to the Tigers. It’s 160mm front armor and 185mm front turret are no easy targets, so you should definitely look for a good target to hit before you shoot that shell.
From the front, you can try to hit the driver on the right, or if you get a really good angle, go for the bottom plate of the hull. Otherwise you should probably look for another solution before you get shredded by its quite impressive arsenal of guns.
While the front is quite tough, the sides are riddled with weak spots, having the ammo rack cover the back third of the turret and the middle of the hull. There’s also a big chance of setting the fire to the big engine block in the back.
The back part of the turret houses the ammo rack on the sides, while the hull has the engine in the middle.
The ammo rack is located on the on both sides of the vehicle, on the back of the turret and also the middle of the sides of the hull.